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Toxicity of D- and L-selenomethionine in Fisher 344 rats

Conference · · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
OSTI ID:5446779
; ; ;
Weanling female Fisher 344 rats were fed ad libitum, a commercial control diet to which was added selenium (Se) as sodium selenite, 16 ppm Se; D- or L-selenomethionine at 10 or 16 ppm Se. Animals (15/diet) were weighted, sacrificed and major organs were weighed, fixed in formalin and frozen for Se analysis. Compared to controls, mean body weights of animals fed 16 ppm Se as selenite, D- or L-selenomethionine were significantly reduced. L-selenomethionine produced the greatest weight reduction at 12 wks of age. D- and L-selenomethionine at 10 ppm Se did not significantly reduce body weight compared to controls. Se toxicity as measured by change in organ weights and histological examination were only observed in animals receiving 16 ppm Se diets. Analysis of liver and muscle at 12 wks of age showed significantly higher Se deposits in rats fed D- or L-selenomethionine than selenite. Slight variations were observed in fecal Se. Large differences in D- and L-selenomethionine toxicities were not observed, but L-selenomethionine appeared to be slightly more toxic. Toxicity was not overt in animals fed 10 ppm Se. Toxicity from Se as selenite was most severe.
Research Organization:
Oklahoma State Univ., Stillwater
OSTI ID:
5446779
Report Number(s):
CONF-8604222-
Conference Information:
Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Journal Volume: 45:3
Country of Publication:
United States
Language:
English

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Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
BODY
CARBOXYLIC ACIDS
DIET
DIGESTIVE SYSTEM
DRUGS
ELEMENTS
GLANDS
LIPOTROPIC FACTORS
LIVER
MAMMALS
METHIONINE
MUSCLES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
RATS
RODENTS
SELENITES
SELENIUM
SELENIUM COMPOUNDS
SEMIMETALS
TOXICITY
VERTEBRATES
WEIGHT