Isotype profiles of anti-influenza antibodies in mice bearing the xid defect
The humoral response to influenza A/PR8 virus was examined in the CAB/N and C/sub 3/J.xid strains of mice, both of which bear an X-linked genetic defect (xid), and in strains lacking this defect. Hemagglutination-inhibiting antibody titers and measurement of virus-specific antibodies by solid-phase radioimmunoassay indicated that the xid defect does not impair the production of an adequate anti-influenza antibody response. However, investigation of the isotopes of PR8 virus-specific antibodies disclosed a relative decrease in the levels of IgG3 and IgG1 in the xid-bearing strains. This was observed after both intraperitoneal immunization and aerosol infection. The isotope differences were not reflected in the susceptibility of these strains to influenza virus infection.
- Research Organization:
- City Univ. of New York, NY
- OSTI ID:
- 5445143
- Journal Information:
- J. Virol.; (United States), Vol. 53:2
- Country of Publication:
- United States
- Language:
- English
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551001* - Physiological Systems- Tracer Techniques