A monoclonal antibody that recognizes B cells and B cell precursors in mice
Journal Article
·
· J. Exp. Med.; (United States)
The monoclonal antibody, RA3-2C2, appears to be specific for cells within the B cell lineage. This antibody does not recognize thymocytes, peripheral T cells, or nonlymphoid hematopoietic cells in the spleen or bone marrow. Nor does it recognize the pluripotent hematopoietic stem cells, the spleen colony-forming unit, All sIg+ B cells and most plasma cells are RA3-2C2+. In addition, approximately 20% of nucleated bone marrow cells are RA3-2C2+ but sIg-. This population contains B cell precursors that can give rise to sIg+ cells within 2 d in vitro.
- OSTI ID:
- 5443686
- Journal Information:
- J. Exp. Med.; (United States), Vol. 153:2
- Country of Publication:
- United States
- Language:
- English
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+1 more
Related Subjects
59 BASIC BIOLOGICAL SCIENCES
ANTIBODIES
SPECIFICITY
BIOCHEMICAL REACTION KINETICS
BLOOD PLASMA
BONE MARROW CELLS
CFU
IN VITRO
LYMPHOCYTES
MICE
PRECURSOR
SPLEEN CELLS
THYMOCYTES
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
KINETICS
LEUKOCYTES
MAMMALS
MATERIALS
REACTION KINETICS
RODENTS
SOMATIC CELLS
VERTEBRATES
550200* - Biochemistry
551000 - Physiological Systems
ANTIBODIES
SPECIFICITY
BIOCHEMICAL REACTION KINETICS
BLOOD PLASMA
BONE MARROW CELLS
CFU
IN VITRO
LYMPHOCYTES
MICE
PRECURSOR
SPLEEN CELLS
THYMOCYTES
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
KINETICS
LEUKOCYTES
MAMMALS
MATERIALS
REACTION KINETICS
RODENTS
SOMATIC CELLS
VERTEBRATES
550200* - Biochemistry
551000 - Physiological Systems