Treatment of non-Hodgkin's lymphoma with marrow transplantation in identical twins
Journal Article
·
· Blood; (United States)
OSTI ID:5441839
Eight patients with disseminated non-Hodgkin's lymphoma who failed conventional combination chemotherapy were treated with high-dose chemotherapy, a supralethal dose of total-body irradiation, and a bone marrow transplant from a normal identical twin. Seven patients experienced complete remission. Four of the seven patients (two with diffuse poorly differentiated lymphocytic lymphoma, one with composite lymphoma, and one with diffuse moderately well differentiated lymphocytic lymphoma) remain in complete unmaintained remission 12-126 mo from transplantation. One patient relapsed after 10 mo but was retreated and is alive in unmaintained complete remission 73 mo from transplantation. One patient died of Pseudomonas pneumonia while in complete remission and one patient relapsed and died of progressive lymphoma. These results demonstrate that intensive chemoradiotherapy and twin marrow transplantation can induce frequent and enduring remissions in patients with disseminated non-Hodgkin's lymphoma who have failed conventional therapy.
- OSTI ID:
- 5441839
- Journal Information:
- Blood; (United States), Journal Name: Blood; (United States) Vol. 58:3; ISSN BLOOA
- Country of Publication:
- United States
- Language:
- English
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OSTI ID:6670186
Related Subjects
550603* -- Medicine-- External Radiation in Therapy-- (1980-)
550900 -- Pathology
560151 -- Radiation Effects on Animals-- Man
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE MARROW
CHEMOTHERAPY
DISEASES
EXTERNAL IRRADIATION
HEMATOPOIETIC SYSTEM
IMMUNOLOGY
IRRADIATION
LYMPHOMAS
MEDICINE
MICROORGANISMS
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATHOLOGY
PATIENTS
PSEUDOMONAS
RADIATION EFFECTS
RADIOLOGY
RADIOTHERAPY
THERAPY
TISSUES
TRANSPLANTS
WHOLE-BODY IRRADIATION
550900 -- Pathology
560151 -- Radiation Effects on Animals-- Man
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE MARROW
CHEMOTHERAPY
DISEASES
EXTERNAL IRRADIATION
HEMATOPOIETIC SYSTEM
IMMUNOLOGY
IRRADIATION
LYMPHOMAS
MEDICINE
MICROORGANISMS
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATHOLOGY
PATIENTS
PSEUDOMONAS
RADIATION EFFECTS
RADIOLOGY
RADIOTHERAPY
THERAPY
TISSUES
TRANSPLANTS
WHOLE-BODY IRRADIATION