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Transcription of interferon-stimulated genes is induced by adenovirus particles but is suppressed by E1A gene products

Journal Article · · J. Virol.; (United States)
OSTI ID:5438195
; ; ;
Interferon treatment of cell cultures results in the rapid transcriptional induction of a specific set of genes. In this paper the authors explore the effect of cellular infection by several adenoviruses, both wild type and mutant, on the expression of these genes. Infection with adenovirus induces the transcription of the interferon-stimulated genes in the absence of any protein synthesis. In fact, the inhibition of protein synthesis during a wild-type infection produces enhanced stimulation of transcription of these genes. Experiments with viral mutants indicate the ability to specifically suppress this transcription maps to the E1A gene. In addition, the E1A gene products are capable of suppressing the specific transcriptional induction of interferon-stimulated promoters during cotransfection experiments and therefore presumably during viral infection. The dual effect of adenovirus on the expression of interferon-stimulated genes may represent an example of action and evolutionary reaction between virus and host.
Research Organization:
Rockefeller Univ., New York, NY
OSTI ID:
5438195
Journal Information:
J. Virol.; (United States), Journal Name: J. Virol.; (United States) Vol. 62:1; ISSN JOVIA
Country of Publication:
United States
Language:
English

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Related Subjects

550201* -- Biochemistry-- Tracer Techniques
550501 -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADENOVIRUS
AUTORADIOGRAPHY
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
DAYS LIVING RADIOISOTOPES
ELECTROPHORESIS
GENE REGULATION
GENES
GROWTH FACTORS
HELA CELLS
INTERFERON
ISOTOPES
LIGHT NUCLEI
LYMPHOKINES
MESSENGER-RNA
MICROORGANISMS
MITOGENS
NUCLEI
NUCLEIC ACIDS
NUCLEOTIDES
ODD-ODD NUCLEI
ONCOGENIC VIRUSES
ORGANIC COMPOUNDS
PARASITES
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
PROTEINS
RADIOISOTOPES
RNA
TRANSCRIPTION
VIRUSES