Primate model for the study of the interaction of /sup 111/In-labeled baboon platelets with dacron arterial prostheses

Journal Article · Sat Mar 01 04:00:00 EST 1980 · Ann. Surg.; (United States)

DOI:https://doi.org/10.1097/00000658-198003000-00017· OSTI ID:5437120

Callow, A D; Ledig, C B; O'Donnell, T F; Kelly, J J; Rosenthal, D; Korwin, S; Hotte, C; Kahn, P C; Vecchione, J J; Valeri, C R

This paper presents early experience with a primate model for the noninvasive study of the interaction of circulating platelets with healing arterial prostheses. These experiments demonstrate that baboon platelets can be isolated and labeled with /sup 111/Indium with high efficiency using a sterile technique. Platelets subjected to this process have a linear life span similar to that of /sup 51/Chromium-labeled baboon platelets. The high energy gamma emission of /sup 111/Indium oxine allows for external scanning using a standard gamma camera. The small quantity of /sup 111/Indium-labeled platelets in the region of the graft can be discriminated from the surrounding blood vessel and quantitated by gamma camera imaging and computer analysis. There was a significant increase in the platelet deposition on prosthetic surfaces observed 5-48 hours after graft implantation and injection of /sup 111/Indium-labeled autologous platelets.

• Research Organization: Naval Blood Research Laboratory, Boston, MA
• OSTI ID: 5437120
• Journal Information: Ann. Surg.; (United States), Journal Name: Ann. Surg.; (United States) Vol. 191:3; ISSN ANSUA
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702 -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
APES
ARTERIES
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL MODELS
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BLOOD VESSELS
BODY
BODY FLUIDS
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DACRON
DATA
DATA FORMS
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
ELECTRON CAPTURE RADIOISOTOPES
ESTERS
EXPERIMENTAL DATA
GRAFTS
INDIUM 111
INDIUM ISOTOPES
INFORMATION
INTERACTIONS
INTERMEDIATE MASS NUCLEI
ISOLATED VALUES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LABELLING
MAMMALS
MATERIALS
MEDICAL SUPPLIES
MINUTES LIVING RADIOISOTOPES
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC POLYMERS
ORGANS
POLYESTERS
POLYMERS
PRIMATES
PROSTHESES
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
TRANSPLANTS
VERTEBRATES