Feasibility study: results of treatment of primary and recurrent adenocarcinoma of the corpus uteri with Californium-252

Journal Article · Sat Jun 01 04:00:00 EDT 1985 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(85)90070-7· OSTI ID:5436575

Maruyama, Y; Kryscio, R; Wood, C; van Nagell, J R; Donaldson, E; Hanson, M; Yoneda, J

A trial of Cf-252 for the radiotherapy of primary or recurrent corpus adenocarcinoma was carried out at the University of Kentucky. The patients with primary tumors were of advanced age, poor general medical condition, and had multiple chronic medical illnesses, poorly differentiated tumors and/or metastatic Stage IVB disease. Fourteen patients with primary tumors were treated and all achieved complete local tumor control. The five year actuarial disease-free survival rate by the Kaplan-Meier method was 100% for Stage I-III disease, although 36% died of other, usually medical, causes. For eight patients treated with recurrent tumors, long term tumor control was 40% four year actuarial disease survival. Local control was 100% for vault recurrences of 3 cm diameter size but only 6/8 (75%) cleared their pelvic tumors completely. Corpus carcinoma was highly sensitive to Cf-252 neutron radiation therapy.

• Research Organization: Univ. of Kentucky Medical Center, Lexington
• OSTI ID: 5436575
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 11:6; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CALIFORNIUM 252
CALIFORNIUM ISOTOPES
CARCINOMAS
DIGESTIVE SYSTEM
DIGESTIVE SYSTEM DISEASES
DISEASES
EVEN-EVEN NUCLEI
FEMALE GENITALS
FISTULAE
GASTROINTESTINAL TRACT
HEAVY NUCLEI
INTESTINES
ISOTOPES
MEDICINE
MEMBRANES
MUCOUS MEMBRANES
NEOPLASMS
NEUTRON THERAPY
NUCLEAR MEDICINE
NUCLEI
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
PROCTITIS
RADIATION EFFECTS
RADIOINDUCTION
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SURVIVAL TIME
THERAPY
USES
UTERUS
YEARS LIVING RADIOISOTOPES