Influence of thorax irradiation on the survival of mice with spontaneous or artificial lung metastases from a transplantable mammary adenocarcinoma
Journal Article
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
The effect of thorax irradiation on lung metastases, either occurring spontaneously from a primary mammary adenocarcinoma (M8013X) transplanted on the leg or artificially induced by intravenous injection of tumor cells was studied. Increasing the interval between the moment at which lung metastases are supposed to originate and the thorax irradiation resulted in a rapid decrease of the effectiveness of this treatment in preventing the development of lung metastases. Increasing the radiation dose led to an increased number of cures; however, an increased number of mice dying of lethal lung damage was also observed. Irradiation of the lungs of mice with 5 or 10 Gy, 24 hours, 7 days or 14 days prior to i.v. injection with tumor cells, did not significantly increase the number of mice with lung metastases. Immunological resistance against the tumor played a role in our experiments with both spontaneous and artificial lung metastases.
- Research Organization:
- Univ. of Amsterdam, Netherlands
- OSTI ID:
- 5436326
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 11:6; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CARCINOMAS
CHEST
DISEASES
DOSES
ELECTROMAGNETIC RADIATION
EXPERIMENTAL NEOPLASMS
GLANDS
IMMUNITY
IONIZING RADIATIONS
LUNGS
MAMMALS
MAMMARY GLANDS
MEDICINE
METASTASES
MICE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOLOGY
RADIOTHERAPY
RESPIRATORY SYSTEM
RODENTS
SIDE EFFECTS
THERAPY
VERTEBRATES
X RADIATION
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CARCINOMAS
CHEST
DISEASES
DOSES
ELECTROMAGNETIC RADIATION
EXPERIMENTAL NEOPLASMS
GLANDS
IMMUNITY
IONIZING RADIATIONS
LUNGS
MAMMALS
MAMMARY GLANDS
MEDICINE
METASTASES
MICE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOLOGY
RADIOTHERAPY
RESPIRATORY SYSTEM
RODENTS
SIDE EFFECTS
THERAPY
VERTEBRATES
X RADIATION