Cardiovascular and endocrine response to hemorrhage after. cap alpha. /sub 1/-blockade in lambs and ewes

Journal Article · Sun Feb 01 04:00:00 EST 1987 · Am. J. Physiol.; (United States)

OSTI ID:5434690

Block, S M; Rose, J C; Ernest, J M; Flowe, K; South, S; Zimmerman, C

To evaluate the role of the ..cap alpha../sub 1/-adrenergic system in the response to hemorrhage during development, lambs and adult sheep were chronically catheterized and hemorrhaged after pretreatment with prazosin or vehicle. The adults became markedly more hypotensive after ..cap alpha../sub 1/-blockade and hemorrhage than after vehicle and hemorrhage, whereas the lambs were no more hypotensive when hemorrhaged after prazosin. In the adults and the lambs hemorrhage produced elevations in plasma renin activity and arginine vasopressin measured by radioimmunoassay. However, after prazosin, the adults had a far greater increase in arginine vasopressin levels than after vehicle treatment.

• Research Organization: Wake Forest Univ., Winston-Salem, NC
• OSTI ID: 5434690
• Journal Information: Am. J. Physiol.; (United States), Journal Name: Am. J. Physiol.; (United States) Vol. 252:2; ISSN AJPHA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AGE DEPENDENCE
ANGIOTENSIN
ANIMALS
BLOOD PRESSURE
BODY
CARDIOVASCULAR AGENTS
DOMESTIC ANIMALS
DRUGS
ENDOCRINE GLANDS
ENZYME ACTIVITY
ENZYMES
GLANDS
GLOBULINS
HEMORRHAGE
HOMEOSTASIS
HORMONES
HYDROLASES
IMMUNOASSAY
IMMUNOLOGY
ISOTOPE APPLICATIONS
MAMMALS
NONSPECIFIC PEPTIDASES
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PEPTIDE HORMONES
PEPTIDE HYDROLASES
PHYSIOLOGY
PITUITARY HORMONES
PROTEINS
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNOLOGY
RENIN
RUMINANTS
SHEEP
SYMPTOMS
TRACER TECHNIQUES
VASOCONSTRICTORS
VASOPRESSIN
VERTEBRATES