Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Mercury-binding proteins from the marine mussel, Mytilus edulis

Journal Article · · Environ. Health Perspect.; (United States)
DOI:https://doi.org/10.1289/ehp.866545· OSTI ID:5431372

The marine mussel, Mytilus edulis, possesses low molecular weight, metal-binding proteins which can be induced by and, in turn, bind mercury when individuals are exposed to low, but elevated concentrations of mercury as HgCl/sub 2/. Induction of the proteins by exposure of mussels to copper, cadmium, or mercury is associated with enhanced tolerance to mercury toxicity. Mercury-binding proteins isolated from gills of mussels occur as two molecular weight variants of about 20-25 and 10-12 kdaltons, respectively, on Sephadex G-75. These have been designated as HgBP/sub 20/ and HgBP/sub 10/ following the nomenclature used for cadmium-binding proteins. HgBP/sub 20/ represents the primary mercury-binding species. Separation of HgBP/sub 20/ by anion-exchange high-performance liquid chromatography resulted in the resolution of six peaks, indicating a more complex situation than was evident from DEAE-cellulose separations. Although not completely purified, these also contain cysteine- and glycine-rich proteins.

Research Organization:
Pennsylvania State Univ., University Park
DOE Contract Number:
AC06-76RL01830
OSTI ID:
5431372
Journal Information:
Environ. Health Perspect.; (United States), Journal Name: Environ. Health Perspect.; (United States) Vol. 65; ISSN EVHPA
Country of Publication:
United States
Language:
English

Similar Records

Cadmium-binding proteins in the mussel, Mytilus edulis
Journal Article · Fri Feb 28 23:00:00 EST 1986 · Environ. Health Perspect.; (United States) · OSTI ID:5431373
Metabolism and toxicity of trace metals by the mussel, Mytilus edulis. Final report
Technical Report · Tue Dec 31 23:00:00 EST 1985 · OSTI ID:5002148
Mercury-binding proteins of Mytilus edulis
Conference · Sat Oct 31 23:00:00 EST 1981 · OSTI ID:5428928

Related Subjects

550200 -- Biochemistry
560304* -- Chemicals Metabolism & Toxicology-- Invertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AQUATIC ORGANISMS
BIOCHEMISTRY
BIOLOGICAL EFFECTS
CHEMISTRY
CHLORIDES
CHLORINE COMPOUNDS
CHROMATOGRAPHY
GILLS
HALIDES
HALOGEN COMPOUNDS
INVERTEBRATES
ION EXCHANGE CHROMATOGRAPHY
MERCURY CHLORIDES
MERCURY COMPOUNDS
MERCURY HALIDES
METALLOPROTEINS
MOLECULAR WEIGHT
MOLLUSCS
MUSSELS
ORGANIC COMPOUNDS
PROTEINS
RESPIRATORY SYSTEM
SEPARATION PROCESSES