MFO activity in carp (Cyprinus carpio) exposed to treated pulp and paper mill effluent in Lake Coleman, Victoria, Australia, in relation to AOX, EOX, and muscle PCDD/PCDF

Journal Article · Sat Jan 01 04:00:00 EST 1994 · Environmental Toxicology and Chemistry; (United States)

DOI:https://doi.org/10.1002/etc.5620130108· OSTI ID:5429814

Ahokas, J T; Holdway, D A; Brennan, S E ^[1]; Goudey, R W; Bibrowska, H B ^[2]

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1. Royal Melbourne Inst. of Tech., Victoria (Australia). Key Centre for Applied and Nutritional Toxicology
2. Environment Protection Authority, Victoria (Australia). Marine Studies Group

European carp (Cyprinus carpio) exposed to highly treated pulp mill effluent in Lake Coleman, a shallow-water lake in southern Victoria, Australia, had significantly elevated hepatic microsomal EROD levels relative to reference fish from a nearby unexposed water body. Mean hepatic microsomal EROD activity appeared to be correlated with site adsorbable organic halogen (AOX) levels, with a simple linear regression yielding the equation Y = 0.059 X + 1.415 (r[sup 2] = 0.93, n = 5), where Y is mean EROD activity in nanomoles per minute per milligram and X is mean AOX concentration in micrograms per liter. Mean liver EROD activity was poorly related with fish muscle-tissue extractable organic halogen (EOX) and sediment EOX concentrations. Hepatic microsomal EROD activity also appeared to be correlated with the low levels of PCDD/PCDFs measured in carp muscle. Simple linear regression of mean EROD activity in carp liver with the mean fish muscle dioxin content yielded the equation Y = 6.514X + 5.754 (n = 4, r[sup 2] = 0.88), where Y is mean EROD activity in nanomoles per minute per milligram and X is mean dioxin concentration in ppt of TCDD TEs. Hepatic microsomal ECOD activity, however, was not significantly different at any exposure site from the reference sites. Overall, Lake Coleman contained between 4.5 and 9.3 times the water AOX levels, 0.8 and 13.7 times the sediment EOX levels, 1.5 and 2.2 times the carp muscle-fat EOX levels, 5.0 and 5.3 times the carp whole-muscle TCDD toxic equivalents, and 6.5 times the carp fat TCDD toxic equivalents, compared to reference samples. Within Lake Coleman, mean liver microsomal EROD activity levels were 2.3 to 6.3 times higher than the reference sites, respectively.

• OSTI ID: 5429814
• Journal Information: Environmental Toxicology and Chemistry; (United States), Journal Name: Environmental Toxicology and Chemistry; (United States) Vol. 13:1; ISSN ETOCDK; ISSN 0730-7268
• Country of Publication: United States
• Language: English

Related Subjects

54 ENVIRONMENTAL SCIENCES
540320* -- Environment
Aquatic-- Chemicals Monitoring & Transport-- (1990-)
560300 -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AQUATIC ORGANISMS
AUSTRALASIA
AUSTRALIA
CHEMICAL EFFLUENTS
CHEMICAL WASTES
DEVELOPED COUNTRIES
ENZYME ACTIVITY
ENZYMES
FISHES
INDUSTRY
LAKES
MIXED-FUNCTION OXIDASES
NONRADIOACTIVE WASTES
ORGANIC COMPOUNDS
OXIDOREDUCTASES
OXYGENASES
PAPER INDUSTRY
POLLUTION
PROTEINS
SENSITIVITY
SURFACE WATERS
VERTEBRATES
VICTORIA
WASTES
WATER POLLUTION
WOOD PRODUCTS INDUSTRY