The effect of iron on the biodistribution of bone scanning agents in humans

Journal Article · Wed Jul 01 04:00:00 EDT 1981 · Radiology; (United States)

DOI:https://doi.org/10.1148/radiology.140.1.6264545· OSTI ID:5427885

Choy, D; Murray, I P; Hoschl, R

Nine patients with chronic iron overload, resulting from either repeated transfusions or hemochromatosis, had bone scans that were characterized by a reduction of bony uptake, marked increase in renal activity, and a significant increase in soft-tissue accumulation of 99mTc-labeled bone-seeking agents. These findings were supported by semiquantitative computer analysis. The probable mechanisms of altered biodistribution and the possible role of serum ferritin are discussed. The importance of realizing the effect of excess iron on skeletal scintigraphy is further emphasized by the results of bone scanning in another patient in whom acute iron overload following infusion of iron-dextran resulted in excessive blood pool labeling.

• OSTI ID: 5427885
• Journal Information: Radiology; (United States), Journal Name: Radiology; (United States) Vol. 140:1; ISSN RADLA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
BONE SEEKERS
BUILDUP
CHEMICAL ANALYSIS
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISTRIBUTION
ELEMENTS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IRON
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MATERIALS
METALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATIENTS
QUANTITATIVE CHEMICAL ANALYSIS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
SKELETON
TECHNETIUM 99
TECHNETIUM ISOTOPES
THERAPY
TISSUE DISTRIBUTION
TRANSFUSIONS
TRANSITION ELEMENTS
USES
YEARS LIVING RADIOISOTOPES