Normal dexamethasone-suppression adrenal scintiscan

Journal Article · Thu Nov 01 04:00:00 EST 1979 · J. Nucl. Med.; (United States)

OSTI ID:5421966

Gross, M D; Freitas, J E; Swanson, D P; Brady, T; Beierwaltes, W H

To establish the parameters of adrenal imaging under dexamethasone suppression (DS), 18 normotensive, normal male volunteers underwent dexamethasone-suppression adrenal scintiscanning. Five control groups were established and given dexamethasone, either 8 mg for 2 days or 4 mg for 7 days before 6..beta..-(/sup 131/1)iodomethyl-norcholesterol (NP-59) administration. NP-59 was given in doses of 2, 1, or 0.5 mCi. Early visualization (3-5 days) of the adrenals was noted in the groups on the 8 mg DS regimen with either 1 or 2 mCi of NP-59. Late visualization (5-7 days) was noted in the groups that received 4 mg DS and either 2, 1, or 0.5 mCi of MP-59, respectively. The normal adrenal will demonstrate uptake of NP-59 under DS, and the duration of DS before imaging is the critical factor as to when discernible adrenal visualization will occur. The documentation of the normal suppression interval on these DS regimens provides a basis for the correct diagnostic interpretation of adrenal hyperfunction as seen on the dexamethasone-suppression NP-59 adrenal scan.

• Research Organization: Univ. of Michigan Medical Center, Ann Arbor
• OSTI ID: 5421966
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 20:11; ISSN JNMEA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL GLANDS
ADRENAL HORMONES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CORTICOSTEROIDS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DEXAMETHASONE
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DOSE-RESPONSE RELATIONSHIPS
DYNAMIC FUNCTION STUDIES
ENDOCRINE GLANDS
GLANDS
GLUCOCORTICOIDS
HORMONES
HYDROXY COMPOUNDS
INHIBITION
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOTOPES
KETONES
MALES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PREGNANES
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
SCINTISCANNING
STEROID HORMONES
STEROIDS
TIME DEPENDENCE
UPTAKE
USES