Effect of 8 hours oxygen breathing at 2 atmosphere on glucose utilization in the rat

Conference · Sat Mar 01 04:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:5417234

Torbati, D

The regional cerebral metabolic rate for glucose (rCMRg1) was previously measured by (/sup 1/$C) 2-deoxyglucose autoradiographic method in conscious rats exposed to 2 atmosphere absolute oxygen (ATA O/sub 2/) up to 4 hours, and during various pre-convulsive periods of brain oxygen toxicity at 3 and 5 ATA O/sub 2/. The exposures at 2 ATA O/sub 2/ did not produce any visible signs of pulmonary or brain oxygen toxicity as judged by lack of changes in the respiratory pattern and normal behavior. However, 1 h exposure to 2 ATA O/sub 2/ produced significant increases in rCMRg1 in various neuroanatomical structures. These increases were diminished following 4 h exposure to 2 ATA O/sub 2/. In the present study the exposure time for rCMRg1 measurement was extended to 8 h oxygen breathing at 2 ATA O/sub 2/, when obvious signs of respiratory distress developed. The data demonstrate no changes in rCMRg1 of the 28 neuroanatomical structures examined during oxygen breathing and normoxia at 2 ATA as compared to air breathing rats at 1 ATA. Thus, the early increases in rCMRg1 at 2 ATA O/sub 2/ seem to be a transient physiological phenomenon. It is concluded that unlike exposures to 3 and 5 ATA O/sub 2/, the respiratory system at 2 ATA O/sub 2/ in conscious rats is more sensitive to the toxic effects of oxygen than the central nervous system.

• Research Organization: Univ. of Pennsylvania, Philadelphia
• OSTI ID: 5417234
• Report Number(s): CONF-8604222-
• Conference Information: Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Journal Volume: 45:3
• Country of Publication: United States
• Language: English

Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALDEHYDES
ANIMALS
ANOXIA
AUTORADIOGRAPHY
BODY
BRAIN
CARBOHYDRATES
CARBON 14 COMPOUNDS
CENTRAL NERVOUS SYSTEM
ELEMENTS
GLUCOSE
HEXOSES
LABELLED COMPOUNDS
MAMMALS
METABOLISM
MONOSACCHARIDES
NERVOUS SYSTEM
NONMETALS
ORGANIC COMPOUNDS
ORGANS
OXYGEN
RATS
RESPIRATION
RESPIRATORY SYSTEM
RODENTS
SACCHARIDES
SENSITIVITY
TOXICITY
VERTEBRATES