Quantitative planar imaging with technetium-99m methoxyisobutyl isonitrile: Comparison of uptake patterns with thallium-201
- Univ. of Virginia Health Sciences Center, Charlottesville (USA)
To compare the myocardial uptake pattern of 99mTc-labeled methoxyisobutyl isonitrile (( 99mTc) MIBI) and 201TI, planar scintigraphy were performed in both patients with documented coronary artery disease and subjects with a low likelihood of disease. Quantitative analysis was employed using a standard interpolative background subtraction algorithm and a new algorithm modified to better accommodate for the differences in extracardiac activity seen with (99mTc)MIBI rest images. Among patients with coronary artery disease, the standard algorithm yielded no significant difference in relative defect magnitude between (99mTc)MIBI and 201TI on stress scintigrams (p = 0.48), although the magnitude of (99mTc)MIBI defects was greater on resting images (p = 0.02). When the modified algorithm was employed, defect magnitude was similar for both stress (p = 0.91) and rest (p = 0.20) images. Normal segmental uptake ratios derived from a comparison of contralateral segments (e.g., septal:posterolateral) in the low likelihood patients were similar for both (99mTc)MIBI and 201TI. Thus, modification of the standard interpolative background subtraction algorithm is necessary for quantitative planar (99mTc)MIBI perfusion imaging. When appropriate background subtraction is employed, myocardial uptake and quantitative defect magnitude of (99mTc)MIBI and 201TI planar images are similar.
- OSTI ID:
- 5411480
- Journal Information:
- Journal of Nuclear Medicine; (USA), Vol. 30:9; ISSN 0161-5505
- Country of Publication:
- United States
- Language:
- English
Similar Records
Technetium-99m hexakis 2-methoxyisobutyl isonitrile: Human biodistribution, dosimetry, safety, and preliminary comparison to thallium-201 for myocardial perfusion imaging
Quantitative rotational tomography with /sup 201/Tl and /sup 99m/Tc 2-methoxy-isobutyl-isonitrile. A direct comparison in normal individuals and patients with coronary artery disease
Related Subjects
CARDIOVASCULAR DISEASES
DIAGNOSIS
HEART
SCINTISCANNING
ALGORITHMS
COMPARATIVE EVALUATIONS
EXERCISE
ISOMERIC NUCLEI
NITRILES
ORGANOMETALLIC COMPOUNDS
PATIENTS
PERFUSED ORGANS
TECHNETIUM 99
THALLIUM 210
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MATHEMATICAL LOGIC
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
TECHNETIUM ISOTOPES
THALLIUM ISOTOPES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics