Antibody-mediated radiotherapy

Journal Article · Wed May 01 00:00:00 EDT 1985 · Cancer (Philadelphia); (United States)

DOI:https://doi.org/10.1002/1097-0142(19850501)55:9+<2229::AID-CNCR2820551427>3.0.CO;2-X· OSTI ID:5407606

Bloomer, W D; Lipsztein, R; Dalton, J F

Antibodies that react with antigens on the surface of tumor cells but not normal cells have great potential for cancer detection and therapy. If radiolabeled without loss of immunologic specificity, such antibodies may be able to deliver cytoxic amounts of radiation. Target- cell specificity and a high extraction coefficient are necessary with any radionuclide in order to minimize normal tissue irradiation. Tumor- cell-retention time and the rate of catabolized radionuclide will also influence ultimate applicability. Among the unanswered questions for choosing a radionuclide is the choice of particle emitter. Although classic beta emitters have been used in a number of clinical situations, they have not had a major impact on disease outcome except in diseases of the thyroid. Unfortunately, Auger emitters such as iodine 125 are cytotoxic only when localized within close proximity to the genome. On the other hand, alpha emitters such as astatine 211 eliminate the need for subcellular sequestration but not cell-specific localization. 34 references.

• Research Organization: Mount Sinai Medical Center, New York, NY
• OSTI ID: 5407606
• Journal Information: Cancer (Philadelphia); (United States), Vol. 55:Suppl. 9
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
NEOPLASMS
DIAGNOSIS
IMMUNOTHERAPY
RADIOTHERAPY
TUMOR CELLS
ANTIGEN-ANTIBODY REACTIONS
ALPHA PARTICLES
ANTIBODIES
ASTATINE 211
BETA PARTICLES
IODINE 125
ALPHA DECAY RADIOISOTOPES
ANIMAL CELLS
ASTATINE ISOTOPES
BETA DECAY RADIOISOTOPES
CHARGED PARTICLES
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
RADIOISOTOPES
RADIOLOGY
THERAPY
550603* - Medicine- External Radiation in Therapy- (1980-)
550601 - Medicine- Unsealed Radionuclides in Diagnostics