Liquid chromatography/time-of-flight mass spectrometry with high-speed integrated transient recording
- Johns Hopkins Univ., Baltimore (USA)
- Univ. of Maryland, Baltimore (USA)
- Kratos Analytical, Manchester (England)
High-performance liquid chromatography (HPLC) has been interfaced to a time-of-flight mass spectrometer. The interface is a continuous flow probe and ions are desorbed from the liquid matrix by energetic ion bombardment. Pulsed and delayed ion extraction from the source permits the use of broad ionization times, results in the production of analog signals in each time-of-flight cycle, and provides both energy and spatial focusing. A high-speed integrated transient recording system has been developed and is also reported. This instrument is the prototype for development of a high-speed, high-mass range LC detector with high duty cycle. Its performance is demonstrated for the separation of several mixtures of small peptides.
- OSTI ID:
- 5406942
- Journal Information:
- Analytical Chemistry (Washington); (United States), Vol. 62:13; ISSN 0003-2700
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
LIQUID COLUMN CHROMATOGRAPHY
MEASURING INSTRUMENTS
MASS SPECTROSCOPY
DATA ACQUISITION SYSTEMS
MEASURING METHODS
PEPTIDES
TIME-OF-FLIGHT MASS SPECTROMETERS
CHROMATOGRAPHY
DYNAMIC MASS SPECTROMETERS
MASS SPECTROMETERS
ORGANIC COMPOUNDS
PROTEINS
SEPARATION PROCESSES
SPECTROMETERS
SPECTROSCOPY
TIME-OF-FLIGHT SPECTROMETERS
400201* - Chemical & Physicochemical Properties