Leukotriene-induced radioprotection of hematopoietic stem cells in mice
Journal Article
·
· Radiat. Res.; (United States)
Leukotrienes (LTs), known primarily for their pathological roles, may also be capable of exerting cytoprotection against toxic agents in a manner similar to that of prostaglandins. In this report, it is shown that treatment of mice with leukotrienes C4, D4, E4, or B4 prior to sublethal irradiation increased the number of endogenous hematopoietic stem cells (E-CFU), with LTC4 producing the greatest response (LTC4 much greater than B4 greater than E4 greater than D4). LTC4-induced hematopoietic radioprotection was examined in greater detail using the exogenous spleen colony (CFU-S) and granulocyte/macrophage progenitor cell (GM-CFC) assays. The dose reduction factors for these cells in LTC4-treated mice at radiation doses resulting in 37% cell survival were 1.65 and 2.01, respectively.
- Research Organization:
- Armed Forces Radiobiology Research Institute, Bethesda, MD (USA)
- OSTI ID:
- 5406615
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 113:2; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ARACHIDONIC ACID
BODY
CARBOXYLIC ACIDS
CELL PROLIFERATION
HEMATOPOIETIC SYSTEM
IRRADIATION
MAMMALS
MICE
MONOCARBOXYLIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
RADIATION PROTECTION
RADIOSENSITIVITY EFFECTS
RODENTS
SOMATIC CELLS
STEM CELLS
SUBLETHAL IRRADIATION
SURVIVAL CURVES
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ARACHIDONIC ACID
BODY
CARBOXYLIC ACIDS
CELL PROLIFERATION
HEMATOPOIETIC SYSTEM
IRRADIATION
MAMMALS
MICE
MONOCARBOXYLIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
RADIATION PROTECTION
RADIOSENSITIVITY EFFECTS
RODENTS
SOMATIC CELLS
STEM CELLS
SUBLETHAL IRRADIATION
SURVIVAL CURVES
VERTEBRATES