The influence of the surgical wound on local tumor recurrence
- Univ. of Virginia Medical Center, Charlottesville (USA)
Failure of a primary surgical treatment for cancer is often caused by recurrence of the tumor at the surgical site. The KHT mouse tumor system recapitulates this experience and provides a useful model to test strategies for reducing the incidence of local recurrence after surgical excision. There was an 82% local recurrence of the KHT tumor after surgery. A cell dilution assay indicated that it would require only 39 tumor cells injected into the wound site to result in the same (82%) incidence of tumors. This figure is in contrast to 340 cells required when the cells were injected into an unwounded flank. With the B16 melanoma in C57B1 mice and the Meth A sarcoma in BALB/c mice, the number of cells necessary to induce a tumor (TD/50) was also significantly reduced when the cells were injected into a surgical wound rather than into nonwounded tissue. The difference in cell number was interpreted as the result of the presence of growth factors derived from the traumatized tissue and the inflammatory cells at the wound site. Neither a 5 nor a 15 Gy dose of x-radiation delivered to the wound site immediately after surgical excision of the KHT tumor resulted in a significant reduction in the incidence of local recurrences. When the same doses of x-radiation were given immediately after injecting 36 KHT cells into a wound, no tumors developed. This difference was believed to have resulted from the hypoxic condition in the wound site and the presence of residual clonogenic tumor cells in a nonproliferating (radioresistant) state.
- OSTI ID:
- 5405161
- Journal Information:
- Surgery; (USA), Vol. 106:3; ISSN 0039-6060
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
ANOXIA
RADIOSENSITIVITY EFFECTS
TUMOR CELLS
CELL PROLIFERATION
DISEASE INCIDENCE
EXPERIMENTAL NEOPLASMS
GROWTH FACTORS
MELANOMAS
MICE
RADIATION DOSES
SARCOMAS
SURGERY
WOUNDS
X RADIATION
ANIMAL CELLS
ANIMALS
DISEASES
DOSES
ELECTROMAGNETIC RADIATION
INJURIES
IONIZING RADIATIONS
MAMMALS
MEDICINE
MITOGENS
NEOPLASMS
ORGANIC COMPOUNDS
PROTEINS
RADIATIONS
RODENTS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals
550600 - Medicine