Estimation of infarct size by determination of myocardial 3H-tetracycline accumulation in the coronary ligated rat
Journal Article
·
· Res. Commun. Chem. Pathol. Pharmacol.; (United States)
OSTI ID:5404579
Myocardial infarction was produced in rats by ligation of the left coronary artery. Rats were injected with 3H-tetracycline (50 muCi/kg) i.p., 10 minutes prior to ligation. The rats were killed at various time periods after ligation and the myocardial accumulation of 3H-tetracycline determined in the left ventricle or in whole heart homogenates. CPK was also determined in the myocardium or serum. Myocardial 3H-tetracycline was not significantly elevated in the whole heart homogenates. However, there was a significant increase in 3H-tetracycline in the digests of the left ventricle 6 h post-infarct. This increase correlated very well with serum CPK activity. This suggest that this method could be a useful tool in the estimation of infarct size.
- Research Organization:
- Department of Pharmacodynamics and Toxicology, College of Pharmacy, University of Nebraska Medical Center, Omaha
- OSTI ID:
- 5404579
- Journal Information:
- Res. Commun. Chem. Pathol. Pharmacol.; (United States), Journal Name: Res. Commun. Chem. Pathol. Pharmacol.; (United States) Vol. 34:1; ISSN RCOCB
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ARTERIES
BLOOD SERUM
BLOOD VESSELS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CORONARIES
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
HEART
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MYOCARDIAL INFARCTION
ORGANS
RATS
RODENTS
SIZE
TETRACYCLINES
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ARTERIES
BLOOD SERUM
BLOOD VESSELS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CORONARIES
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
HEART
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MYOCARDIAL INFARCTION
ORGANS
RATS
RODENTS
SIZE
TETRACYCLINES
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES