Time course of /sup 99m/Tc(Sn)-tetracycline uptake in experimental acute myocardial infarction

Journal Article · Mon Dec 01 04:00:00 EST 1975 · J. Nucl. Med., v. 16, no. 12, pp. 1144-1146

OSTI ID:4146516

Holman, B L; Zweiman, F G

The relative concentration of /sup 99m/Tc(Sn)-tetracycline in infarcted myocardium was determined as a function of time after coronary artery occlusion in mongrel dogs. The concentration ratio (infarct-to-normal myocardium) was highest within the first 2 days after occlusion (6.7 +- 0.5 at 1 day and 8.0 +- 1.6 at 2 days). By 1 week after occlusion the ratio had fallen to 1.9 +- 0.2. In the region of infarction, the concentration of /sup 99m/Tc(Sn)- tetracycline was homogeneously distributed across the inner three-quarters of the myocardial wall; the outer quarter of the wall had substantially lower concentrations during the first 5 days after infarction. The present study confirms the observation suggested in initial investigations in man that scintigraphy performed with /sup 99m/Tc(Sn)-tetracycline will distinguish between acute and chronic myocardial infarctions. (auth)

• Research Organization: Harvard Medical School, Boston
• NSA Number: NSA-33-007665
• OSTI ID: 4146516
• Journal Information: J. Nucl. Med., v. 16, no. 12, pp. 1144-1146, Journal Name: J. Nucl. Med., v. 16, no. 12, pp. 1144-1146; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

*MYOCARDIAL INFARCTION-- DIAGNOSIS
*MYOCARDIUM-- SCINTISCANNING
*SCINTISCANNING-- TECHNETIUM 99
550601* --Biomedical Sciences
Basic Studies--Medicine-- Unsealed Radionuclides in Diagnostics
ISOMERIC NUCLEI
LABELLED COMPOUNDS
N48830* --Life Sciences--New Tracer Techniques--Other
PATENTS
TETRACYCLINES
TIN COMPLEXES