Evaluation of /sup 99m/Tc stannous pyrophosphate as an imaging agent in acute myocardial infarction

Journal Article · Thu Jul 01 04:00:00 EDT 1976 · Circulation; (United States)

OSTI ID:7310971

Bruno, F P; Cobb, F R; Rivas, F; Goodrich, J K

Serial /sup 99m/Tc pyrophosphate scintigrams were obtained 7 hr to 15 days after experimental acute myocardial infarction produced by permanent or transient coronary occlusion. Scintigrams were interpreted visually and the increased radioactivity in the precordial image was quantitated and compared to extent of infarction found histologically. Results of these studies indicate: (1) /sup 99m/Tc pyrophosphate imaging is an extremely sensitive technique for detection of acute myocardial infarction, i.e., infarction in excess of 1% of the left ventricular mass was detected. (2) Early detection of acute infarction is a function of blood flow since 7 hr after infarction, scans were negative after permanent occlusion but were strongly positive after transient occlusion. (3) Radioactivity in the precordial image was inversely related to extent of infarction after transient occlusion. (4) /sup 99m/Tc pyrophosphate localized in areas with significant histologic infarction but the distribution of radioactivity was not proportional to extent of infarction.

• Research Organization: Veterans Administration Hospital, Durham, NC
• OSTI ID: 7310971
• Journal Information: Circulation; (United States), Journal Name: Circulation; (United States) Vol. 54:1; ISSN CIRCA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DOGS
HEART
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MUSCLES
MYOCARDIAL INFARCTION
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OXYGEN COMPOUNDS
PHOSPHORUS COMPOUNDS
PYROPHOSPHATES
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
TECHNETIUM 99
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES