Effects of lindane on calcium fluxes in synaptosomes

Journal Article · · NeuroToxicology; (USA)

OSTI ID:5404127

Hawkinson, J E; Shull, L R; Joy, R M ^[1]

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1. Univ. of California, Davis (USA)

The effect of lindane on {sup 45}Ca fluxes in synaptosomes was examined to determine whether modulation of calcium regulation can explain the lindane-induced enhancement in neurotransmitter release observed in other preparations. Lindane (0.03 - 4.6 microM) enhanced calcium uptake in non-depolarizing (low K+) medium: the effect was maximal at 0.1 microM lindane, which increased uptake by 15.8%. Lindane (11.5 microM) decreased calcium uptake in depolarizing (high K+) medium; lower concentrations were ineffective. In addition, lindane (9.2 microM) increased early {sup 45}Ca release from synaptosomes. However, lindane (2.4 or 5.9 microM) had no effect on calcium uptake by lysed synaptosomes in the presence or absence of mitochondrial poisons and/or ATP, indicating that lindane does not affect sub-cellular calcium storage. It is concluded that the lindane-induced changes in synaptosomal calcium flux are due to an increase in non-specific synaptic membrane permeability to calcium.

• OSTI ID: 5404127
• Journal Information: NeuroToxicology; (USA), Journal Name: NeuroToxicology; (USA) Vol. 10:1; ISSN NRTXD; ISSN 0161-813X
• Country of Publication: United States
• Language: English

Related Subjects

550501 -- Metabolism-- Tracer Techniques
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH ISOTOPES
ALKALINE EARTH METALS
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
CALCIUM
CALCIUM 45
CALCIUM ISOTOPES
CELL CONSTITUENTS
CELL MEMBRANES
CHLORINATED ALICYCLIC HYDROCARBONS
DAYS LIVING RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
HALOGENATED ALICYCLIC HYDROCARBONS
INSECTICIDES
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LINDANE
MAMMALS
MEMBRANE TRANSPORT
MEMBRANES
METALS
NERVE CELLS
NUCLEI
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
PERMEABILITY
PESTICIDES
RADIOISOTOPES
RATS
RODENTS
SOMATIC CELLS
TRACER TECHNIQUES
VERTEBRATES