Particulate oil shale inhalation and pulmonary inflammatory response in rats

Technical Report · Sat Jan 01 04:00:00 EST 1983

DOI:https://doi.org/10.2172/5402587· OSTI ID:5402587

Wilson, J S; Holland, L M; Halleck, M S; Martinez, E; Saunders, G

This experiment detrimetal that long-term inhalation of shale dusts by rats elicits a limited inflammatory response in the lung less profound than that observed in animals exposed to equivalent levels of quartz alone. This observation suggests that organic and inorganic constituents of shale may provide a protective effect. The implications for fibrogenic disease are two-fold: (1) inhalation of oil shale dusts appeared to be less detriemtal than the inhalation of quartz along, and (2) there was no apparent synergistic action of quartz and the complex of organic materials present in shale. Animals exposed to shale dusts failed to develop any significant lung lesions, while all of the animals exposed to quartz developed granulomas and some frank fibrosis.

• Research Organization: Los Alamos National Lab., NM (USA)
• DOE Contract Number: W-7405-ENG-36
• OSTI ID: 5402587
• Report Number(s): LA-UR-83-3583; CONF-8309189-1; ON: DE84004319
• Country of Publication: United States
• Language: English

Related Subjects

04 OIL SHALES AND TAR SANDS
040700 -- Oil Shales & Tar Sands-- Health & Safety
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
AMINO ACIDS
ANIMAL CELLS
ANIMALS
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BITUMINOUS MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARBONACEOUS MATERIALS
CARBOXYLIC ACIDS
CHALCOGENIDES
CHEMICAL ANALYSIS
CONNECTIVE TISSUE CELLS
DATA
ENERGY SOURCES
ENZYME ACTIVITY
EXPERIMENTAL DATA
FOSSIL FUELS
FUELS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HISTOLOGY
HYDROXY ACIDS
HYDROXYPROLINE
INFORMATION
INHALATION
INTAKE
LAVAGE
LEUKOCYTES
LUNGS
LYMPHOCYTES
MAMMALS
MATERIALS
MINERALS
NUMERICAL DATA
OIL SHALES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDE MINERALS
OXIDES
OXYGEN COMPOUNDS
PARTICLES
PARTICULATES
PYRROLES
PYRROLIDINES
QUANTITATIVE CHEMICAL ANALYSIS
QUARTZ
RATS
RESPIRATORY SYSTEM
RODENTS
SILICON COMPOUNDS
SILICON OXIDES
SOMATIC CELLS
VERTEBRATES