The Langerhans cell
Langerhans cells are the bone-marrow-derived immune cells of the epidermis; they express Ia antigens and receptors for the Fc portion of IgG and complement components and are required for epidermal-cell-induced antigen-specific, syngeneic and allogeneic T-cell activitation and the generation of epidermal-cell-induced cytotoxic T cells. Their presence within the epidermis and functional integrity determine whether topical application of haptens leads to specific sensitization or unresponsiveness, and in skin grafts of only I region disparate donors, they represent the cells responsible for the critical allosensitizing signal. UV radiation abrogates most of Langerhans cell functions in vitro; under certain conditions in vivo, it prevents contact sensitization favoring the development of specific unresponsiveness. UV radiation abrogates antigen-presenting capacities of epidermal cells by interfering both with the processing of antigen by Langerhans cells and the production of the epidermal-cell-derived thymocyte activating factor required for optimal T-cell responses.
- Research Organization:
- Department of Dermatology I, University of Vienna, Austria
- OSTI ID:
- 5394832
- Journal Information:
- J. Invest. Dermatol.; (United States), Vol. 80
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BONE MARROW CELLS
BIOLOGICAL RADIATION EFFECTS
EPIDERMIS
IMMUNITY
ULTRAVIOLET RADIATION
BIOLOGICAL EFFECTS
DERMATITIS
GRAFT-HOST REACTION
IMMUNOLOGY
LYMPHOCYTES
ANIMAL CELLS
ANIMAL TISSUES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DISEASES
ELECTROMAGNETIC RADIATION
EPITHELIUM
LEUKOCYTES
MATERIALS
ORGANS
RADIATION EFFECTS
RADIATIONS
SKIN
SKIN DISEASES
SOMATIC CELLS
TISSUES
550300* - Cytology
560121 - Radiation Effects on Cells- External Source- (-1987)