Initial evaluation of developmental malformation as an end point in mixture toxicity hazard assessment for aquatic vertebrates

Journal Article · Mon Apr 01 04:00:00 EST 1991 · Ecotoxicology and Environmental Safety; (United States)

DOI:https://doi.org/10.1016/0147-6513(91)90023-I· OSTI ID:5394684

Dawson, D A; Wilke, T S ^[1]

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1. Department of Animal Science, College of Veterinary Medicine, University of Tennessee, Knoxville (USA)

The joint toxic action of three binary mixtures was determined for the embryo malformation endpoint of the aquatic FETAX (frog embryo teratogenesis assay: Xenopus) test system. Osteolathyrogenic compounds and short-chain carboxylic acids, representing separate, distinct modes of action for induction of malformation, were selected for testing in 96-hr, static-renewal tests. Three mixtures were tested for each combination, with each combination being tested on three separate occasions. Using toxic unit analysis, the combination of osteolathyrogens and the combination of carboxylic acids produced strictly additive (concentration addition) rates of malformation, while the combination of an osteolathyrogen and a carboxylic acid was less-than-additive (response addition) for induction of malformation. Therefore, developmental malformation may have value as an endpoint in mixture toxicity hazard assessment.

• OSTI ID: 5394684
• Journal Information: Ecotoxicology and Environmental Safety; (United States), Journal Name: Ecotoxicology and Environmental Safety; (United States) Vol. 21:2; ISSN EESAD; ISSN 0147-6513
• Country of Publication: United States
• Language: English

Related Subjects

54 ENVIRONMENTAL SCIENCES
540320* -- Environment
Aquatic-- Chemicals Monitoring & Transport-- (1990-)
560300 -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMPHIBIANS
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIMICROBIAL AGENTS
AQUATIC ORGANISMS
BIOLOGICAL INDICATORS
CARBOXYLIC ACIDS
CONGENITAL MALFORMATIONS
DRUGS
EMBRYOS
FROGS
HYDRAZIDES
ISONIAZID
MALFORMATIONS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATHOLOGICAL CHANGES
POLLUTION
SCREENING
TERATOGEN SCREENING
VERTEBRATES
WATER POLLUTION