Effect of fluoride on the intestinal epithelial cell brush border membrane
Journal Article
·
· Bull. Environ. Contam. Toxicol.; (United States)
Fluoride consumed by man and animals is chiefly absorbed in the intestine. Chronic fluoride exposure causes mottled teeth and osteosclerosis. Over-fluoridation (126 mM) of drinking water have been reported to cause nausea, vomiting and diarrhea. Furthermore, the effect of acute and low concentrations of fluoride on gastric secretion, ion transport and other disorders have also been studied. Fluoride also causes alterations in the permeability of membranes and membrane bound enzymes. The intestinal cell lining plays an important role in digestion and absorption. It automatically becomes the most exposed site of contact to fluoride following ingestion. Earlier study have shown significant alterations in the formation of lipid peroxides in rat intestine following oral administration of fluoride. The present study was undertaken to investigate the damage of rat intestinal epithelium in situ caused by relatively high and low fluoride concentrations.
- Research Organization:
- Industrial Toxicology Research Centre, Lucknow, India
- OSTI ID:
- 5393850
- Journal Information:
- Bull. Environ. Contam. Toxicol.; (United States), Journal Name: Bull. Environ. Contam. Toxicol.; (United States) Vol. 39:1; ISSN BECTA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Radiation-induced recurrent intestinal pseudo-obstruction
St. John's wort attenuates irinotecan-induced diarrhea via down-regulation of intestinal pro-inflammatory cytokines and inhibition of intestinal epithelial apoptosis
Toxicokinetic study of rat intestinal brush border membrane enzymes following in vitro exposure to lead and vanadium
Journal Article
·
Mon Jun 01 00:00:00 EDT 1981
· Am. J. Gastroenterol.; (United States)
·
OSTI ID:5308254
St. John's wort attenuates irinotecan-induced diarrhea via down-regulation of intestinal pro-inflammatory cytokines and inhibition of intestinal epithelial apoptosis
Journal Article
·
Sun Oct 15 00:00:00 EDT 2006
· Toxicology and Applied Pharmacology
·
OSTI ID:20850443
Toxicokinetic study of rat intestinal brush border membrane enzymes following in vitro exposure to lead and vanadium
Journal Article
·
Wed Jun 01 00:00:00 EDT 1994
· Bulletin of Environmental Contamination and Toxicology; (United States)
·
OSTI ID:6849649
Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ACID ANHYDRASES
ALKALINE PHOSPHATASE
ANIMAL TISSUES
ANIMALS
ATP-ASE
BIOLOGICAL EFFECTS
BODY
DIGESTIVE SYSTEM
ENZYME ACTIVITY
ENZYMES
EPITHELIUM
ESTERASES
ESTERS
FLUORIDES
FLUORINE COMPOUNDS
GASTROINTESTINAL TRACT
HALIDES
HALOGEN COMPOUNDS
HYDROLASES
INGESTION
INTAKE
INTESTINAL ABSORPTION
INTESTINES
LIPIDS
MALES
MAMMALS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
PHOSPHATASES
PHOSPHOHYDROLASES
PHOSPHOLIPIDS
RATS
RODENTS
TISSUES
UPTAKE
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ACID ANHYDRASES
ALKALINE PHOSPHATASE
ANIMAL TISSUES
ANIMALS
ATP-ASE
BIOLOGICAL EFFECTS
BODY
DIGESTIVE SYSTEM
ENZYME ACTIVITY
ENZYMES
EPITHELIUM
ESTERASES
ESTERS
FLUORIDES
FLUORINE COMPOUNDS
GASTROINTESTINAL TRACT
HALIDES
HALOGEN COMPOUNDS
HYDROLASES
INGESTION
INTAKE
INTESTINAL ABSORPTION
INTESTINES
LIPIDS
MALES
MAMMALS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
PHOSPHATASES
PHOSPHOHYDROLASES
PHOSPHOLIPIDS
RATS
RODENTS
TISSUES
UPTAKE
VERTEBRATES