In vivo and in vitro dermal penetration of lipophilic and hydrophilic pesticides in mice

Journal Article · Mon Jun 01 04:00:00 EDT 1987 · Bull. Environ. Contam. Toxicol.; (United States)

DOI:https://doi.org/10.1007/BF01609073· OSTI ID:5393798

Grissom, Jr, R E; Brownie, C; Guthrie, F E

Dermal absorption is a major portal of entry for a wide variety of potentially toxic substances. In vivo and in vitro investigations assessing penetration of topically applied xenobiotics using both human and other animals have been conducted. Current ethical considerations have drastically curtailed the testing of xenobiotics in human volunteers; consequently, dermal penetration in humans is usually estimated from in vivo tests in animals and in vitro tests using either human or animal skin. In order for in vitro penetration results to be meaningful, there needs to be close relationship with in vivo data. The objective of the present study was to investigate the relationship between in vivo and in vitro penetration of both hydrophilic and lipophilic /sup 14/C-labelled compounds in mice.

• Research Organization: North Carolina State Univ., Raleigh
• OSTI ID: 5393798
• Journal Information: Bull. Environ. Contam. Toxicol.; (United States), Journal Name: Bull. Environ. Contam. Toxicol.; (United States) Vol. 38:6; ISSN BECTA
• Country of Publication: United States
• Language: English

Related Subjects

550501 -- Metabolism-- Tracer Techniques
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ANIMALS
AROMATICS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CARBON 14 COMPOUNDS
COUNTING TECHNIQUES
DDT
FECES
IN VITRO
IN VIVO
INSECTICIDES
LABELLED COMPOUNDS
MAMMALS
MATERIALS
METABOLISM
MICE
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
PESTICIDES
RODENTS
SCINTILLATION COUNTING
SKIN
SKIN ABSORPTION
UPTAKE
URINE
VERTEBRATES
WASTES