Effect of sex on the characteristics of autonomic receptors in lower urinary tract

Conference · Sat Mar 01 04:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:5393539

Latifpour, J; O'Hollaren, B; Morita, T; Wheeler, M A; Weiss, R M

Since there are conflicting reports regarding the composition of autonomic receptors in the lower urinary tract, characteristics of adrenergic and muscarinic cholinergic receptors were investigated in six month old male and female rabbits. The authors utilized the /sup 3/H-prazosin (PZ), /sup 3/H-yohimbine (YOH), /sup 3/H-dihydroalprenolol (DHA) and /sup 3/H-quinuclidinyl benzylate (QNB) to label alpha-1, alpha-2, and beta adrenergic and muscarinic receptors, respectively, in plasma membranes of bladder base, bladder dome and urethra. Saturation experiments were performed to determine K/sub D and B/sub max/ values. K/sub D/ values for each labeled ligand were similar in all examined tissues and sexes.

• Research Organization: Yale Univ. School of Medicine, New Haven, CT
• OSTI ID: 5393539
• Report Number(s): CONF-8604222-
• Conference Information: Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Journal Volume: 45:3
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BODY
CELL CONSTITUENTS
CELL MEMBRANES
DRUGS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LIGANDS
MAMMALS
MEMBRANE PROTEINS
MEMBRANES
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RABBITS
RECEPTORS
SEX DEPENDENCE
SYMPATHOMIMETICS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
URINARY TRACT
VERTEBRATES