Therapeutic use of fractionated total body and subtotal body irradiation
Ninety-one patients were treated using fractionated subtotal body (STBI) or total body irradiation (TBI). These patients had generalized lymphomas, Hodgkin's disease, leukemias, myelomas, seminomas, or oat-cell carcinomas. Subtotal body irradiation is delivered to the entire body, except for the skull and extremities. It was expected that a significantly higher radiation dose could be administered with STBI than with TBI. STBI was given when there was a reasonable likelihood that malignancy did not involve the shielded volumes. A five- to ten-fold increase in tolerance for STBI was demonstrated. Many of these patients have had long-term (up to 17 year--.permanent) remissions. There is little or no treatment-induced symptomatology, and no sanctuary sites. STBI and TBI are useful therapeutic modalities for many of these malignancies.
- OSTI ID:
- 5390960
- Journal Information:
- Cancer (Philadelphia); (United States), Vol. 47:9
- Country of Publication:
- United States
- Language:
- English
Similar Records
A phase I study of WR-2721 in combination with total body irradiation (TBI) in patients with refractory lymphoid malignancies
Combined modality therapy of diffuse histology non-Hodgkin's lymphoma with cyclophosphamide, adriamycin, vincristine, prednisone (CHOP) and total body irradiation
Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
DISEASES
BIOLOGICAL RADIATION EFFECTS
NEOPLASMS
COMPARATIVE EVALUATIONS
FRACTIONATED IRRADIATION
HEMOGLOBIN
PARTIAL BODY IRRADIATION
PATIENTS
RADIATION DOSES
RADIOTHERAPY
TOLERANCE
BIOLOGICAL EFFECTS
CARBOXYLIC ACIDS
DOSES
EXTERNAL IRRADIATION
GLOBIN
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
IRRADIATION
MEDICINE
NUCLEAR MEDICINE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PIGMENTS
PORPHYRINS
PROTEINS
RADIATION EFFECTS
RADIOLOGY
THERAPY
550603* - Medicine- External Radiation in Therapy- (1980-)
560151 - Radiation Effects on Animals- Man