Heterogeneous chiral catalysis: Past, present, and future
- Argonne National Lab., IL (United States)
In order to improve the scalability of the synthesis of chiral compounds, considerable effort has been devoted to the design of heterogeneous chiral catalysts. The attachment of {open_quotes}curved{close_quotes} chiral ligands, such as cinchona alkaloids, to supported metal complexes has permitted enantioselectivities approaching those in homogeneous solution. While the nature of the support has received less attention, the increased pore structure control gained during the gradual shift from polymeric supports to pillared clays, and finally to mesoporous zeolites and controlled pore glasses will hopefully allow better molecular size and shape control. Future work in this area likely will entail the use of polymeric templates as molecular imprints for protein synthesis and for antibody delivery systems.
- OSTI ID:
- 539093
- Report Number(s):
- CONF-960807--
- Country of Publication:
- United States
- Language:
- English
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