Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Concentration of 3H-8-methoxypsoralen and its metabolites in the rat lens and eye after a single oral administration

Journal Article · · Invest. Ophthalmol. Visual Sci.; (United States)
OSTI ID:5390086
;
Concentrations of 3H-8-methoxypsoralen (MOP), its lipid- and water-soluble metabolites, tritiated water, and an insoluble compound have been measured in rat serum, lens, and eye tissue by liquid scintillation, thin-layer chromatography, and other techniques. The radioactivity has been measured in albino and pigmented rats up to 1 week after medication, and 3H-8-MOP and metabolite concentrations have been measured in pigmented rats from 10 min to 24 hr after oral administration by stomach tube of a solution of 3H-8-MOP (1 mg/kg body weight). The animals were kept in the dark. The maximum 3H-8-MOP concentrations were seen 10 min after medication in all the organs examined. The concentrations (in microgram/kg) at 10 min, 2 hr, and 24 hr, respectively, after medication were: serum, 698, 55, and 0.8; lens, 11.3, 5.2, and 1.4; other eye tissue, 393, 23, and 2.5. Water soluble metabolites might accumulate in the lens, but the absolute concentration is small. There was no accumulation of metabolites in the other organs. The considerable amount of radioactivity still present in tissues 1 week after a single medication was a result of the formation of tritiated water from the degraded 3H-8-MOP.
Research Organization:
Department of Dermatology, The Finsen Institute, Copenhagen, Denmark
OSTI ID:
5390086
Journal Information:
Invest. Ophthalmol. Visual Sci.; (United States), Journal Name: Invest. Ophthalmol. Visual Sci.; (United States) Vol. 22:1; ISSN IOVSD
Country of Publication:
United States
Language:
English

Similar Records

Distribution of 3H-8-MOP and its metabolites in rat organs after a single oral administration
Journal Article · Tue Mar 31 23:00:00 EST 1981 · J. Invest. Dermatol.; (United States) · OSTI ID:5858821
Kinetics of (/sup 14/C-5) 8-methoxypsoralen uptake by UVA irradiated and non-irradiated rabbit eye tissues
Journal Article · Fri May 01 00:00:00 EDT 1981 · Res. Commun. Chem. Pathol. Pharmacol.; (United States) · OSTI ID:5405231
Dose-dependent elimination of 8-methoxypsoralen in the mouse
Conference · Fri Feb 28 23:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) · OSTI ID:5496851

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BIOLOGICAL ACCUMULATION
BLOOD SERUM
BODY
BODY AREAS
CHROMATOGRAPHY
COUMARIN
CRYSTALLINE LENS
ESTERS
EYES
FACE
HEAD
HETEROCYCLIC COMPOUNDS
LABELLED COMPOUNDS
LACTONES
LIQUID SCINTILLATION DETECTORS
MAMMALS
MEASURING INSTRUMENTS
METABOLITES
ORAL ADMINISTRATION
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PYRANS
RADIATION DETECTORS
RATS
RODENTS
SCINTILLATION COUNTERS
SENSE ORGANS
SEPARATION PROCESSES
THIN-LAYER CHROMATOGRAPHY
TRITIUM COMPOUNDS
VERTEBRATES