Effect of dietary selenium (Se) on the development of fusarium-induced tibial dyschondroplasia (FITD) in broiler chickens

Conference · Sat Mar 01 04:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:5387277

Walser, M M; Levander, O A

The purposes of this study were to determine the effect of low and high levels of dietary Se on the pathogenesis of FITD and to use the findings to assess the applicability of FITD as an animal model of Kashin-Beck disease. Day-old female broiler chickens were assigned to 1 or 3 diets: low Se (0.02 ppm), normal Se (0.15 ppm), and high Se (0.5 ppm). At 1 week of age, dosing of 15 of 26 chicks in each dietary group with TDP-1, the toxic component of fusarium roseum Graminearum was begun. Chicks were terminated from 24 to 30 days of age. The mortality rate of the TDP-1-treated chicks on the high Se diet was significantly less than that in the other TDP-treated groups. There were no differences in the incidence, severity, or character of the FITD lesions among the dietary groups. Neither diet nor TDP-1 treatment affected hematocrit levels. Plasma Se and hepatic glutathione peroxidase activity were significantly lower in the low Se dietary group than in other groups. The nature of the lesion of FITD and the time course of its development are distinct from the features of Kashin-Beck disease. Administration of a high dietary level of Se did not affect the development of FITD.

• Research Organization: Univ. of Minnesota, St. Paul
• OSTI ID: 5387277
• Report Number(s): CONF-8604222-
• Conference Information: Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Journal Volume: 45:3
• Country of Publication: United States
• Language: English

Related Subjects

550900 -- Pathology
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIRDS
CHICKENS
DIET
DISEASES
ELEMENTS
ENZYME ACTIVITY
ENZYMES
FOWL
FUNGI
FUSARIUM
INFECTIOUS DISEASES
OXIDOREDUCTASES
PARASITES
PARASITIC DISEASES
PATHOGENESIS
PEROXIDASES
PLANTS
SELENIUM
SEMIMETALS
TOXICITY
VERTEBRATES