Comparative effect of lidocaine and bupivacaine on glucose uptake and lactate production in the perfused working rat heart

Conference · Sat Mar 01 00:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:5386285

Cronau, Jr, L H; Merin, R G; Aboulish, E; Steenberg, M L; Maljorda, A

It has been suggested that at equivalent therapeutic concentrations, lidocaine and bupivacaine may have different cardiotoxic potency. In the isolated working rat heart preparation, the effect of a range of lidocaine and bupivacaine concentrations on glucose uptake and lactate production (LP) were observed. Insulin was added, 10 ..mu../L, to Ringer's solution containing /sup 3/H-labeled glucose to measure the glycolytic flux (GF). The effect of the local anesthetics on LP at the indicated concentrations were similar. Lidocaine appears to depress the glycolytic flux from exogenous glucose to a lesser degree. Bupivacaine, 10 mg/L, depresses VO/sub 2/ to a greater degree than does lidocaine, 40 mg/L.

• Research Organization: Univ. of Texas Medical School, Houston
• OSTI ID: 5386285
• Report Number(s): CONF-8604222-; TRN: 86-026527
• Journal Information: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Vol. 45:3; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ANESTHETICS
BIOLOGICAL EFFECTS
GLUCOSE
UPTAKE
LACTATES
BIOSYNTHESIS
COMPARATIVE EVALUATIONS
INSULIN
RATS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ALDEHYDES
ANIMALS
CARBOHYDRATES
CARBOXYLIC ACID SALTS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DRUGS
HEXOSES
HORMONES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MONOSACCHARIDES
ORGANIC COMPOUNDS
PEPTIDE HORMONES
RODENTS
SACCHARIDES
SYNTHESIS
VERTEBRATES
550201* - Biochemistry- Tracer Techniques