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Effect of copper deficiency on plasma and adrenal catecholamines

Conference · · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
OSTI ID:5381885
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Copper (Cu) ion is an essential component of enzymes involved in catecholamine (CAT) metabolism. Copper deficiency (CuD) has been shown to affect the CAT content of brain (decreased norepinephrine (NE) and dopamine (DA)) and heart (increased DA and decreased NE). It is thus possible that plasma and adrenal CAT could be altered by CuD. The authors, then, investigated the effect of CuD on plasma and adrenal CAT in rats fed copper-deficient (0.6 ..mu..g Cu/g) or copper-supplemented (6.0 ..mu..g Cu/g) diets with either 62% starch (S) or fructose (F) as the carbohydrate source for 7 weeks after weaning. CuD was ascertained by decreased plasma Cu and ceruloplasmin activity. CuD increased the levels of all three CAT (NE, P < 0.001, epinephrine (E), P < 0.0001 and DA, P < 0.01) in plasma, but had no effect on adrenal CAT content. Dietary F had no significant effect on plasma CAT compared to S but did increase E in adrenal tissue (P < 0.001). They have previously demonstrated that CuD is accompanied by increased plasma glucose, triglyceride and cholesterol and decreased insulin. Thus, increased plasma CAT along with decreased plasma insulin may explain, in part, the glucose intolerance and abnormal lipid metabolism observed in CuD.

Research Organization:
Dept. of Agriculture, Beltsville, MD
OSTI ID:
5381885
Report Number(s):
CONF-8604222-
Journal Information:
Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Vol. 45:3; ISSN FEPRA
Country of Publication:
United States
Language:
English

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Related Subjects

560305* -- Chemicals Metabolism &amp; Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL GLANDS
ADRENAL HORMONES
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD PLASMA
BODY
BODY FLUIDS
BRAIN
CARBOHYDRATES
CARDIOTONICS
CARDIOVASCULAR AGENTS
CARDIOVASCULAR SYSTEM
CATECHOLAMINES
CENTRAL NERVOUS SYSTEM
CERULOPLASMIN
COMPLEXES
COPPER
COPPER COMPLEXES
DOPAMINE
DRUGS
ELEMENTS
ENDOCRINE GLANDS
FRUCTOSE
GLANDS
GLOBULINS
GLOBULINS-ALPHA
HEART
HEXOSES
HORMONES
HYDROXY COMPOUNDS
KETONES
MAMMALS
MATERIALS
METABOLISM
METALLOPROTEINS
METALS
MONOSACCHARIDES
NERVOUS SYSTEM
NEUROREGULATORS
NORADRENALINE
NUTRITIONAL DEFICIENCY
ORGANIC COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
POLYSACCHARIDES
PROTEINS
RATS
REAGENTS
RODENTS
SACCHARIDES
STARCH
STEROID HORMONES
SYMPATHOMIMETICS
TRANSITION ELEMENT COMPLEXES
TRANSITION ELEMENTS
VERTEBRATES