Constituent bioconcentration in rainbow trout exposed to a complex chemical mixture
Classically, aquatic contaminant fate models predicting a chemical's bioconcentration factor (BCF) are based upon single-compound derived models, yet such BCF predictions may deviate from observed BCFs when physicochemical interactions or biological responses to complex chemical mixture exposures are not adequately considered in the predictive model. Rainbow trout were exposed to oil-shale retort waters. Such a study was designed to model the potential biological effects precluded by exposure to complex chemical mixtures such as solid waste leachates, agricultural runoff, and industrial process waste waters. Chromatographic analysis of aqueous and nonaqueous liquid-liquid reservoir components yielded differences in mixed extraction solvent HPLC profiles of whole fish exposed for 1 and 3 weeks to the highest dilution of the complex chemical mixture when compared to their corresponding control, yet subsequent whole fish extractions at 6, 9, 12, and 15 weeks into exposure demonstrated no qualitative differences between control and exposed fish. Liver extractions and deproteinized bile samples from exposed fish were qualitatively different than their corresponding controls. These findings support the projected NOEC of 0.0045% dilution, even though the differences in bioconcentration profiles suggest hazard assessment strategies may be useful in evaluating environmental fate processes associated with complex chemical mixtures. 12 references, 4 figures, 2 tables.
- OSTI ID:
- 5380350
- Journal Information:
- Bull. Environ. Contam. Toxicol.; (United States), Vol. 33:3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
04 OIL SHALES AND TAR SANDS
02 PETROLEUM
LIQUID WASTES
BIOLOGICAL EFFECTS
BIOLOGICAL LOCALIZATION
UPTAKE
AGRICULTURE
CHROMATOGRAPHY
LEACHATES
LIVER
MIXTURES
OIL SPILLS
RUNOFF
SHALE TAR WATER
SOLID WASTES
TROUT
ANIMALS
AQUATIC ORGANISMS
BODY
DIGESTIVE SYSTEM
DISPERSIONS
ENVIRONMENTAL TRANSPORT
FISHES
GLANDS
HYDROGEN COMPOUNDS
INDUSTRY
MASS TRANSFER
ORGANS
OXYGEN COMPOUNDS
SEPARATION PROCESSES
SOLUTIONS
VERTEBRATES
WASTE WATER
WASTES
WATER
520200* - Environment
Aquatic- Chemicals Monitoring & Transport- (-1989)
041000 - Oil Shales & Tar Sands- Environmental Aspects
020900 - Petroleum- Environmental Aspects