Potentially lethal radiation damage repair and its inhibition by hyperthermia in normal hamster cells, mouse cells, and transformed mouse cells
Journal Article
·
· Radiat. Res.; (United States)
The capacity of plateau-phase Chinese hamster V79 and normal and transformed C3H-10T1/2 cells for repair of potentially lethal radiation damage (PLD) was evaluated for cells irradiated alone or given combined treatments of heat and radiation. The data show that all cell lines tested could repair PLD and that transformation to the tumorigenic state may reduce the capacity to repair PLD, especially if cells are evaluated at equal survival levels. Hyperthermia treatments before irradiation produced less sensitization than treatments after irradiation. In addition, hyperthermia treatment led to the inhibition of cellular capacity to repair PLD. This effect was the greatest for cells heated after irradiation, and repair of PLD could be completely eliminated. Several temperature isodose heat treatments were evaluated, and the lower temperature heat treatments were more effective in the inhibition of PLD than the higher temperature heat treatments; this is consistent with earlier results indicating temperature dependence in thermal radiosensitization.
- Research Organization:
- Ottawa Regional Cancer Centre, Ontario (Canada)
- OSTI ID:
- 5380088
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 113:1; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY TEMPERATURE
DNA
DNA REPAIR
ENERGY
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
HAMSTERS
HEAT
HYPERTHERMIA
INHIBITION
IRRADIATION
LETHAL IRRADIATION
MAMMALS
MICE
NUCLEIC ACIDS
ORGANIC COMPOUNDS
RADIATION EFFECTS
RADIOSENSITIVITY EFFECTS
RECOVERY
REPAIR
RODENTS
TEMPERATURE DEPENDENCE
VERTEBRATES
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY TEMPERATURE
DNA
DNA REPAIR
ENERGY
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
HAMSTERS
HEAT
HYPERTHERMIA
INHIBITION
IRRADIATION
LETHAL IRRADIATION
MAMMALS
MICE
NUCLEIC ACIDS
ORGANIC COMPOUNDS
RADIATION EFFECTS
RADIOSENSITIVITY EFFECTS
RECOVERY
REPAIR
RODENTS
TEMPERATURE DEPENDENCE
VERTEBRATES