Effect of N-methylformamide on radiocurability of murine tumors
Journal Article
·
· Radiat. Res.; (United States)
N-Methylformamide (NMF) is a polar solvent with maturational activity, i.e., it induces malignant cells to form more differentiated phenotypes. In addition, it renders tumor cells more sensitive to chemotherapeutic drugs and ionizing radiation. In the present study, NMF failed to augment radiocurability, as measured by the single-dose TCD50 assay, of two murine tumors: an 8-mm fibrosarcoma (FSA) and a 6-mm mammary carcinoma (MCA-K). NMF, at a dose of 300 mg/kg, was given ip daily for several days before and/or after local tumor irradiation.
- Research Organization:
- Univ. of Texas, M. D. Anderson Hospital and Tumor Institute, Houston (USA)
- OSTI ID:
- 5379927
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 113:1; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550600 -- Medicine
550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTINEOPLASTIC DRUGS
CARCINOMAS
COMBINED THERAPY
DISEASES
DRUGS
EXPERIMENTAL NEOPLASMS
FIBROSARCOMAS
MAMMALS
MICE
NEOPLASMS
PHENOTYPE
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RODENTS
SARCOMAS
THERAPY
TUMOR CELLS
VERTEBRATES
550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTINEOPLASTIC DRUGS
CARCINOMAS
COMBINED THERAPY
DISEASES
DRUGS
EXPERIMENTAL NEOPLASMS
FIBROSARCOMAS
MAMMALS
MICE
NEOPLASMS
PHENOTYPE
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RODENTS
SARCOMAS
THERAPY
TUMOR CELLS
VERTEBRATES