Nitrogen dioxide induced changes in level of free fatty acids, triglyceride, esterified fatty acid, ganglioside and lipase activity in the guinea pig brain

Journal Article · Sat Feb 01 00:00:00 EST 1992 · Journal of Environmental Science and Health, Part B; (United States)

DOI:https://doi.org/10.1080/03601239209372767· OSTI ID:5374272

Farahani, H; Hasan, M ^[1]

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1. Interdisciplinary Brain Research Centre, Jawaharlal Nehru Medical College, Aligarh Muslim University, (India)

The biochemical response to controlled inhalation of nitrogen dioxide (NO2) was studied in 18 male guinea pigs. Animals were exposed to 2.5, 5.0, and 10 ppm NO2 for 2h daily for 35 consecutive days, and the results compared with six control animals exposed to filtered air for 2h daily for same period. Five biochemical parameters, including triglyceride, free fatty acids, esterified fatty acid, ganglioside and lipase activity were measured immediately after the last day of exposure. At 2.5 ppm NO2 inhalation no significant changes occurred in any region of the central nervous system (CNS). While as the dose concentration was increased to 5 and 10 ppm nitrogen dioxide, significant dose-related alteration were observed in the levels of triglyceride, free fatty acid, esterified fatty acid, ganglioside and lipase activity in the different regions of the guinea pig CNS.

• OSTI ID: 5374272
• Journal Information: Journal of Environmental Science and Health, Part B; (United States), Vol. 27:1; ISSN 0360-1234
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LIPASES
ENZYME ACTIVITY
NITROGEN DIOXIDE
METABOLISM
BRAIN
CARBOXYLIC ACIDS
DOSE-RESPONSE RELATIONSHIPS
ENVIRONMENTAL EXPOSURE
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CENTRAL NERVOUS SYSTEM
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ESTERASES
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GLYCOLIPIDS
HYDROLASES
INTAKE
MAMMALS
NERVOUS SYSTEM
NITROGEN COMPOUNDS
NITROGEN OXIDES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
PROTEINS
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