TCDD (2,3,7,8-tetrachlorodibenzo-P-dioxin) reduces lipoprotein lipase activity in the adipose tissue of the guinea pig

Journal Article · Tue Jul 31 04:00:00 EDT 1984 · Biochem. Biophys. Res. Commun.; (United States)

DOI:https://doi.org/10.1016/S0006-291X(84)80106-0· OSTI ID:5934560

Brewster, D W; Matsumura, F

TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) adminstered to young male guinea pigs at a dose of 1 ..mu..g/kg (single intraperitoneal injection) caused a large reduction in adipose tissue lipoprotein lipase (LPL) activity. This effect occurred rapidly; a 70% decrease was noticed after 24 hour and 80% of LPL activity was lost by 48 hours when the serum triglyceride levels increased to 175% of control levels. LPL is known to play an important role in controlling the amount of free fatty acids supplied to adipose tissues. Administration of a large dose of glucose to fasted guinea pigs, which have shown a similar weight loss, but less LPL loss than TCDD-treated animals, had the effect of elevating their adipose LPL levels back to a near normal level, whereas the same treatment caused no significant increase in the LPL levels of TCDD-treated animals. Evidence indicates that the TCDD-caused decline in LPL activity is irreversible. As a consequence, the affected guinea pigs are incapable of responding to changes in nutritional status. 36 references, 2 figures, 1 table.

• Research Organization: Michigan State Univ., East Lansing
• OSTI ID: 5934560
• Journal Information: Biochem. Biophys. Res. Commun.; (United States), Journal Name: Biochem. Biophys. Res. Commun.; (United States) Vol. 122:2; ISSN BBRCA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADIPOSE TISSUE
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BODY
CARBOXYLESTERASES
CARBOXYLIC ACIDS
CONNECTIVE TISSUE
DIOXIN
ENZYME ACTIVITY
ENZYMES
ESTERASES
ESTERS
GUINEA PIGS
HETEROCYCLIC COMPOUNDS
HYDROLASES
LIPASE
LIPIDS
MAMMALS
NUTRIENTS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
RODENTS
TISSUES
TRIGLYCERIDES
VERTEBRATES