Tantalum-178-labeled agents for lung and liver imaging

Journal Article · Thu Nov 01 04:00:00 EST 1979 · J. Nucl. Med.; (United States)

OSTI ID:5371501

Neirinckx, R D; Holman, B L; Davis, M A; Zimmerman, R E

Despite its 9.3-min half-life, Ta-178 can be used to produce radiopharmaceuticals for lung and liver imaging. A variety of human serum albumin microspheres and other particulate radiopharmaceuticals were labeled with Ta-178. A period of approximately 10 min was required for their preparation and administration to rats. Extrapolation to the clinical situation suggests that imaging could take place after one half-life of the nuclide has elapsed. We find that satisfactory imaging is possible using Ta-178 radiopharmaceuticals with the Anger camera and a pinhole collimator. Since short imaging times, high spatial resolution, and low patient doses are reasonable objectives in pediatric scintigraphy, these new radiotracers may prove useful for lung and liver imaging in children.

• Research Organization: Harvard Medical School, Boston, MA
• OSTI ID: 5371501
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 20:11; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ALBUMINS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BLOOD SERUM
BODY
COUNTING TECHNIQUES
DATA
DATA FORMS
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISTRIBUTION
DOSES
ELECTRON CAPTURE RADIOISOTOPES
EXPERIMENTAL DATA
GLANDS
HOURS LIVING RADIOISOTOPES
INFORMATION
INTERMEDIATE MASS NUCLEI
ISOLATED VALUES
ISOTOPES
LIVER
LUNGS
MAMMALS
MEDICINE
MICROSPHERES
MINUTES LIVING RADIOISOTOPES
NUCLEI
NUMERICAL DATA
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PEDIATRICS
PROTEINS
RADIATION DOSES
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RATS
RESPIRATORY SYSTEM
RODENTS
SCINTISCANNING
TANTALUM 178
TANTALUM ISOTOPES
TISSUE DISTRIBUTION
VERTEBRATES