Stimulation of mouse megakaryocyte endomitosis by plasma from thrombocytopenic rats

Journal Article · Wed Jan 31 23:00:00 EST 1979 · Proc. Soc. Exp. Biol. Med.; (United States)

DOI:https://doi.org/10.3181/00379727-160-40431· OSTI ID:5370314

Odell, T T; McDonald, T P; Shelton, C; Clift, R

Injection of plasma from thrombocytopenic donor rats resulted in an increase in the endomitotic index of megakaryocytes of recipient mice 32 hr after the initial treatment with plasma. The results suggested a dose-response relationship between the amount of plasma administered and the degree of stimulation of megakaryocytopoiesis. These findings demonstrate that an agent capable of stimulating megakaryocytopoiesis is released in response to thrombocytopenia and that this factor can be successfully transferred between species. They also substantiate the assumption that the increase in peripheral platelet numbers and in platelet labeling after administration of presumptive TSF occurs via stimulation of megakaryocytopoiesis.

• Research Organization: Oak Ridge National Lab., TN
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 5370314
• Journal Information: Proc. Soc. Exp. Biol. Med.; (United States), Journal Name: Proc. Soc. Exp. Biol. Med.; (United States) Vol. 160:2; ISSN PSEBA
• Country of Publication: United States
• Language: English

Related Subjects

550300 -- Cytology
550900* -- Pathology
551000 -- Physiological Systems
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD FORMATION
BLOOD PLASMA
BLOOD PLATELETS
BODY FLUIDS
BONE MARROW CELLS
CELL CONSTITUENTS
CELL NUCLEI
CELL PROLIFERATION
CONNECTIVE TISSUE CELLS
DATA
DATA FORMS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DYNAMIC FUNCTION STUDIES
EXPERIMENTAL DATA
HEMIC DISEASES
INFORMATION
INJECTION
INTAKE
ISOLATED VALUES
MAMMALS
MATERIALS
MICE
MITOTIC INDEX
NUMERICAL DATA
RATS
RESPONSE MODIFYING FACTORS
RODENTS
SOMATIC CELLS
STIMULATION
SUBCUTANEOUS INJECTION
VERTEBRATES