Parallel gastric emptying of nonhydrolyzable fat and water after a solid-liquid meal in humans

Journal Article · Sat May 01 04:00:00 EDT 1982 · Gastroenterology; (United States)

OSTI ID:5368702

Cortot, A; Phillips, S F; Malagelada, J R

Our aim was to examine the control of gastric emptying of the oil phase of a mixed solid and liquid meal. Previous studies had shown that liquid dietary fats normally leave the stomach at a slower rate than does water. We wished to determine whether the slower emptying of fats was due to the physical characteristics of food (lower density and greater viscosity than water), to retardation by duodenal feedback mechanisms, or whether both factors contributed. Thus, we quantified the emptying rates of water and sucrose polyester (a nonabsorbable analog of dietary fat) ingested by healthy volunteers as a mixed solid and liquid meal. Gastric emptying was quantified by an intubation-perfusion method incorporating an occlusive jejunal balloon to facilitate recovery. Four phase-specific, nonabsorbable markers were used. (14C(Sucrose octaoleate and polyethylene glycol were incorporated in the meal and traced the lipid and water phases, respectively; (3H)glycerol triether and phenolsulfonphthalein were used as duodenal recovery markers. Sucrose polyester (substituting for dietary fat) was emptied very rapidly, and at about the same rate as was water, in contrast to natural fat, which empties very slowly. Emptying of water was rapid and comparable to that observed after mixed meals containing natural fat. These results imply that gastric emptying of the oil phase is controlled by receptors sensitive to the hydrolytic products of fat digestion and that the slow emptying of dietary fat is not simply due to its lower density.

• Research Organization: Gastroenterology Unit, Mayo Clinic and Mayo Foundation, Rochester, Minnesota
• OSTI ID: 5368702
• Journal Information: Gastroenterology; (United States), Journal Name: Gastroenterology; (United States) Vol. 82:5 Pt 1; ISSN GASTA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
ADULTS
AGE GROUPS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARBON 14
CARBON 14 COMPOUNDS
CARBON ISOTOPES
DIET
ELDERLY PEOPLE
EVEN-EVEN NUCLEI
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ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
LIPIDS
METABOLISM
MINORITY GROUPS
NUCLEI
ORGANIC COMPOUNDS
POPULATIONS
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