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Early release of surfactant following lung irradiation of alveolar type II cells

Journal Article · · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

At 1 hour, 24 hours, and 1 week following irradiation, studies utilizing LAF /sub 1//J mouse lung showed increase of disaturated alveolar phosphatidylcholine (PC) by radiolabelling and alveolar lavage, thus indicating PC as a nearly immediate post-irradiation biomarker. A corresponding decrease of PC in lung tissue following alveolar lavage correlated with an early decrease of lamellar bodies in type II pneumocytes after irrdiation.

Research Organization:
Univ. of Rochester Cancer Center, NY
OSTI ID:
5368309
Journal Information:
Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 6:1; ISSN IOBPD
Country of Publication:
United States
Language:
English

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