Early physiologic and biochemical effects of thoracic x-irradiation on the pulmonary surfactant system. [Mice]
A study of surfactant physiology and biochemistry was undertaken in mice who received varying doses of x-irradiation to the thorax. During the first 12 weeks after x-irradiation, the period which precedes radiation pneumonitis, there is an increase in the amount of DPC in both the lung and the alveolar surface lining layer. This increase begins about 7 days after irradiation, returns to control levels by 12 weeks, and coincides with a fall in the total number of AM's. Over-all synthesis of DPC in the lung and its transport to the alveolar surface, as determined by incorporation of /sup 3/H from glycerol and /sup 14/C from palmitate into PC in vivo, remained unchanged from control levels. These results may be explained in part by proliferation of type 2 pneumocytes following x-irradiation and by decreased removal of surfactant from the alveolar surface, possibly as a result of the depletion of the AM population. No changes in mechanical properties of the lung or in situ E tis or E surf occurred at this stage, nor were changes detected in the surface properties of the alveolar lavage fluid.
- Research Organization:
- Univ. of Chicago
- OSTI ID:
- 5111555
- Journal Information:
- J. Lab. Clin. Med.; (United States), Journal Name: J. Lab. Clin. Med.; (United States) Vol. 91:3; ISSN JLCMA
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
AMINES
AMMONIUM COMPOUNDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CARBON 14
CARBON ISOTOPES
CHEMISTRY
CHEST
CHOLINE
ELECTROMAGNETIC RADIATION
EVEN-EVEN NUCLEI
HYDROGEN ISOTOPES
HYDROXY COMPOUNDS
IONIZING RADIATIONS
ISOTOPES
LIGHT NUCLEI
LIPOTROPIC FACTORS
LUNGS
MAMMALS
MICE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PHYSIOLOGY
QUATERNARY COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RESPIRATORY SYSTEM
RODENTS
SURFACTANTS
TRITIUM
VERTEBRATES
X RADIATION
YEARS LIVING RADIOISOTOPES