Effect of iron, cobalt, and chromium dust on rabbit alveolar macrophages: a comparison with the effects of nickel dust

Journal Article · Fri Feb 01 04:00:00 EST 1980 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(80)90018-3· OSTI ID:5365414

Johansson, A ^[1]; Lundborg, M; Hellstroem, P A; Camner, P; Keyser, T R; Kirton, S E; Natusch, D F.S.

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1. Univ. of Stockholm, Sweden

In a previous inhalation study, exposure of rabbits to concentrations of 0.5 to 2 mg/m/sup 3/ of metallic nickel dust over a period of 4 weeks produced certain reproducible effects on their lungs. The weight and density of the lungs increased as well as the phagocytic activity and size distribution of the alveolar macrophages. Changes in the ultrastructure of the macrophages and the lung lavage fluid were also seen. In the present study, groups of four rabbits each were exposed to iron dust (0.4 and 1.4 mg/m/sup 3/), cobalt dust (0.2 and 1.3 mg/m/sup 3/), and chromium dust (0.6 and 3.1 mg/m/sup 3/). None of these metals gave the same pattern of effects as the nickel dust. The particles, including the nickel particles, were studied with regard to morphology, surface and bulk composition, specific surface area, and solubility in fluids. The nickel on the nickel particles, together with manganese on the chromium particles were the most soluble components. Otherwise, the nickel particles did not differ substantially from the other particles.

• OSTI ID: 5365414
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 21:1; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BODY
CHROMIUM
COBALT
CONNECTIVE TISSUE CELLS
DATA
DATA FORMS
DUSTS
ELECTRON SPECTROSCOPY
ELEMENTS
EXPERIMENTAL DATA
IMAGES
INFORMATION
INHALATION
INTAKE
IRON
LAVAGE
LUNGS
MACROPHAGES
MAMMALS
METALS
NICKEL
NUMERICAL DATA
ORGANS
PARTICLES
PHAGOCYTES
PHAGOCYTOSIS
RABBITS
RESPIRATORY SYSTEM
SOMATIC CELLS
SPECTROSCOPY
TABLES
TRANSITION ELEMENTS
VERTEBRATES