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Effect of acute administration of cadmium on the disposition of copper, zinc, and iron in the rat

Journal Article · · Environ. Res.; (United States)
; ;
Acute administration of subcutaneous doses of cadmium (0.1 to 1.5 mg/kg) to male rats results in high plasma concentrations of copper 24 hr after treatment. In contrast, plasma zinc and iron levels were markedly reduced. The magnitude and significance of the changes in plasma metal ion concentrations were dependent upon the dose of cadmium administered. Liver copper levels were slightly but not significantly increased, but circulating ceruloplasmin levels increased as the total plasma copper increased. Biliary excretion of copper was markedly inhibited after cadmium administration (subcutaneous and oral) and the degree of inhibition was directly related to the dose. Simultaneous parenteral administration of zinc did not counteract this effect. These results suggest that cadmium blocks the excretion of copper into the bile leading to an accumulation of copper in the liver, which in turn, stimulates the synthesis of ceruloplasmin. The mechanisms by which cadmium may inhibit biliary copper excretion are discussed.
Research Organization:
Univ. of Surrey, Guildford, England
OSTI ID:
5365390
Journal Information:
Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 21:1; ISSN ENVRA
Country of Publication:
United States
Language:
English

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Related Subjects

550200 -- Biochemistry
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ANIMALS
BILE
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL PATHWAYS
BIOSYNTHESIS
BLOOD
BLOOD PLASMA
BODY
BODY FLUIDS
CADMIUM
CERULOPLASMIN
CLEARANCE
COMPLEXES
COPPER
COPPER COMPLEXES
DATA
DATA FORMS
DIGESTIVE SYSTEM
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
EXCRETION
EXPERIMENTAL DATA
GLANDS
GLOBULINS
GLOBULINS-ALPHA
GRAPHS
HOMEOSTASIS
INFORMATION
INHIBITION
IRON
KINETICS
LIVER
MAMMALS
MATERIALS
METALS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RATS
REACTION KINETICS
RODENTS
SYNTHESIS
TABLES
TRANSITION ELEMENT COMPLEXES
TRANSITION ELEMENTS
VERTEBRATES
ZINC