Effect of pressure and intimal damage on /sup 131/I-albumin and (/sup 14/C)sucrose spaces in aorta
To measure the distribution volume for sucrose and albumin in the media of the rabbit thoracic aorta, we studied the uptake of tracers in vitro. In most cases the tracers were applied to both luminal and adventitial surfaces at the same concentration. When transmural convection was prevented by pressurization of the arteries with air, there was a decrease in sucrose space (19% at 70 mmHg and 28% at 180 mmHg) and in albumin space (60% at 70 mmHg and 66% at 180 mmHg), compared with the respective spaces in relaxed arteries (0.42 for sucrose and 0.08 for albumin). Much smaller changes were found when intact vessels were pressurized with liquid (insignificant for sucrose, decreases of 24% at 70 mmHg and 14% at 180 mmHg for albumin). Removal of the endothelium, which increases transmural fluid flux, increased the space for sucrose (not significantly at 70 mmHg and 17% at 180 mmHg) and particularly for albumin (100% at 70 mmHg and 250% at 180 mmHg). We conclude that the interstitial volume and consequently the protein space within the media can be modified both by distending stresses applied to the vessel and by transmural fluid flux.
- Research Organization:
- Imperial College, London, England
- OSTI ID:
- 5359435
- Journal Information:
- Am. J. Physiol.; (United States), Vol. 253
- Country of Publication:
- United States
- Language:
- English
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ALBUMINS
TISSUE DISTRIBUTION
AORTA
BIOLOGICAL STRESS
SACCHAROSE
ALGORITHMS
CARBON 14 COMPOUNDS
ENDOTHELIUM
IODINE 131
RABBITS
TRACER TECHNIQUES
ANIMAL TISSUES
ANIMALS
ARTERIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD VESSELS
BODY
CARBOHYDRATES
CARDIOVASCULAR SYSTEM
DAYS LIVING RADIOISOTOPES
DISACCHARIDES
DISTRIBUTION
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MATHEMATICAL LOGIC
NUCLEI
ODD-EVEN NUCLEI
OLIGOSACCHARIDES
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIOISOTOPES
SACCHARIDES
TISSUES
VERTEBRATES
551001* - Physiological Systems- Tracer Techniques