Comparative mammalian genetic toxicology of shale oil products assayed in vitro and in vivo

Conference · Thu Jul 17 04:00:00 EDT 1980

OSTI ID:5358138

Timourian, H; Carrano, A; Carver, J; Felton, J S; Hatch, F T; Stuermer, D S; Thompson, L H

The objective of this project is to determine the relative toxicity and mutagenicity (genetic toxicity) of crude and hydrotreated shale oil products from the Paraho surface retort. This was achieved by applying a battery of bioassays emphasizing mammalian systems and having both in vitro (cell culture supplemented with microsomes to allow metabolic activation) and short-term in vivo components. The results may be compared with the results from bioassays conducted in other laboratories to obtain a basis to estimate health hazards to humans.

• Research Organization: California Univ., Livermore (USA). Lawrence Livermore National Lab.
• DOE Contract Number: W-7405-ENG-48
• OSTI ID: 5358138
• Report Number(s): UCRL-84557; CONF-800680-3
• Country of Publication: United States
• Language: English

Related Subjects

04 OIL SHALES AND TAR SANDS
041000* -- Oil Shales & Tar Sands-- Environmental Aspects
560301 -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
560302 -- Chemicals Metabolism & Toxicology-- Microorganisms-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BACTERIA
BIOASSAY
CELL CONSTITUENTS
CELL CULTURES
DATA
ENERGY SOURCES
EXPERIMENTAL DATA
FOSSIL FUELS
FUELS
GERM CELLS
IN VITRO
IN VIVO
INFORMATION
MAMMALS
METABOLIC ACTIVATION
MICE
MICROORGANISMS
MICROSOMES
MINERAL OILS
MUTAGEN SCREENING
MUTAGENESIS
MUTATIONS
NUMERICAL DATA
OILS
OOCYTES
ORGANIC COMPOUNDS
ORGANOIDS
OTHER ORGANIC COMPOUNDS
PARAHO PROCESS
RODENTS
SALMONELLA
SCREENING
SHALE OIL
SURVIVAL CURVES
SYNTHETIC FUELS
SYNTHETIC PETROLEUM
TOXICITY
VERTEBRATES