6-Acetyldihydrohomopterin and sepiapterin affect some GTP cyclohydrolase I's and not others
Conference
·
OSTI ID:5357984
The first enzyme in pteridine biosynthesis, GTP cyclohydrolase I, is a likely site for regulation of pteridine biosynthesis to occur. GTP cyclohydrolase I responds to hormonal treatment and is found altered in a variety of mice with genetically based neurological and immunological disorders. Genetic loci can greatly modify the activity of GTP cyclohydrolase: Punch mutant in Drosophila hph-1 in mouse and atypical phenylketonuria in human. This report examines the ability of Ahp and sepiapterin to alter the activity of GTP cyclohydrolase I from mouse liver, rat liver and Drosophila head. 20 refs., 2 tabs.
- Research Organization:
- Oak Ridge National Lab., TN (USA); Tennessee Univ., Oak Ridge (USA). Graduate School of Biomedical Sciences
- DOE Contract Number:
- AC05-84OR21400
- OSTI ID:
- 5357984
- Report Number(s):
- CONF-880361-1; ON: DE88006778
- Country of Publication:
- United States
- Language:
- English
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Journal Article
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Fri Dec 31 23:00:00 EST 1976
· Biochem. Genet.; (United States)
·
OSTI ID:6934904
Formation of. beta. ,. gamma. -methylene-7,8-dihydroneopterin 3'-triphosphate from. beta. ,. gamma. -methyleneguanosine 5'-triphosphate by GTP cyclohydrolase I of Escherichia coli
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Sat Dec 31 23:00:00 EST 1983
· Arch. Biochem. Biophys.; (United States)
·
OSTI ID:5932805
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Journal Article
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Mon Mar 31 23:00:00 EST 1986
· Anal. Biochem.; (United States)
·
OSTI ID:5528037
Related Subjects
550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AROMATICS
AZAARENES
CARBON 14 COMPOUNDS
CYCLASES
DOCUMENT TYPES
ENZYMES
FRACTIONATION
HETEROCYCLIC COMPOUNDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LYASES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PROGRESS REPORT
PTERIDINES
SEPARATION PROCESSES
TRACER TECHNIQUES
59 BASIC BIOLOGICAL SCIENCES
AROMATICS
AZAARENES
CARBON 14 COMPOUNDS
CYCLASES
DOCUMENT TYPES
ENZYMES
FRACTIONATION
HETEROCYCLIC COMPOUNDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LYASES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PROGRESS REPORT
PTERIDINES
SEPARATION PROCESSES
TRACER TECHNIQUES